RTU MIREA has introduced films for cystitis, an effective alternative to tablets.

Exploring the possibility of creating a new pharmaceutical form, scientists from the M.V. Lomonosov Institute of Fine Chemical Technologies at RTU MIREA are developing oral films that combine the benefits of traditional medications while eliminating their drawbacks. The advantages of this new form include rapid onset of therapeutic effects, high bioavailability, and ease of use.

“When treating cystitis, it is crucial to start therapy as soon as the first symptoms appear. In this case, the oral film is an ideal solution – it is easy to carry since it takes up little space and can be taken without water when necessary,” explains Maria Zolotareva, senior lecturer at the Department of Biotechnology and Industrial Pharmacy at RTU MIREA.

“When placed in the mouth, the film gradually dissolves, releasing the active ingredients, and the direct contact with the mucosal surface allows these substances to enter the body more quickly. The use of the film simplifies medication intake, especially since both active components (cranberry extract and D-mannose) are included in a single film, eliminating the need to take them separately, which enhances patient comfort and promotes better adherence to the treatment regimen.”

The films are produced by casting from a solvent onto a substrate or into a mold and are dried at temperatures ranging from 40 to 80 degrees for a specific period, depending on the dosage of the medication and its composition. The films are flexible sheets measuring between one to three square centimeters. The color of the film depends on the medication used. In the case of films for cystitis treatment, they are pink due to the addition of cranberry extract.

The research methodology includes determining the flavonoid content in the cranberry extract using spectrophotometry, assessing the film's dissolution time, and testing its antibacterial activity. The results confirm the effectiveness of the developed approach and its potential for the prevention and treatment of inflammatory diseases of the urogenital tract.